Interferon-β in multiple sclerosis: altering the balance of interleukin-12 and interleukin-10?
- 1 June 2001
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Neurology
- Vol. 14 (3), 361-368
- https://doi.org/10.1097/00019052-200106000-00016
Abstract
Interferon-beta is a remarkably pleiotropic molecule. Antiviral, pro- and antiproliferative, pro- and antiapoptotic, and complex immunoregulatory activities have all been described. The precise mechanism(s) that underlie the beneficial effects of interferon-beta in multiple sclerosis remain poorly understood; this has hindered progress in the search for more effective therapies. An increasing body of literature supports the hypothesis that interferon-beta-mediated changes in the production and activities of the immunoregulatory cytokines interleukin-12 and interleukin-10 are important to the therapeutic benefits of interferon-beta in multiple sclerosis. These data are reviewed here.Keywords
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