Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo
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Open Access
- 21 October 2004
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 19 (1), 1-11
- https://doi.org/10.1096/fj.04-2370com
Abstract
Transforming growth factor-β (TGF-β) is the single most important cytokine promoting renal fibrogenesis. p21-activated kinase-2 (PAK2) and activa- tion of abelson nonreceptor tyrosine kinase (c-abl) ...Keywords
Funding Information
- U.S. Public Health Service (GM54200, GM55816)
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases (DK63360)
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