Effects of caffeine on pancreatic tumorigenesis by 4-hydroxyamino-quinoline 1-oxide in partially pancreatectomized rats
- 1 January 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 4 (1), 17-22
- https://doi.org/10.1093/carcin/4.1.17
Abstract
The effects of caffeine on pancreatic tumorigenesis by 4-hydroxyaminoquinoline 1-oxide (4-HAQO) and on pancreatic DNA synthesis were studied in partially pancreatec-tomized male Wistar rats. 4-HAQO was injected i.v. as a single dose of 7 mg/kg body weight 3 days after partial pan-createctomy. Caffeine was injected s.c. every 12 h at the maximum tolerated dose (m.t.d.) of 120 mg/kg body weight, half the m.t.d., and one quarter the m.t.d. from 12 to 72 h before and 0 to 72, 72 to 132, and 0 to 132 h after 4-HAQO treatment. Post-treatment with caffeine from 0 to 132 h had a dose-dependent biphasic effect on pancreatic tumorigenesis: post-treatment with the m.t.d. of caffeine decreased the total number of nodules, whereas treatment with one quarter the m.t.d. of caffeine increased their number. Decrease in the number of nodules was also observed on post-treatment with the m.t.d. of caffeine from 0 to 72 or from 72 to 132 h. Pre-treatment with the m.t.d. of caffeine had no significant effect on the number of nodules. Recovery of pancreatic DNA synthesis was slower after simultaneous treatment with the m.t.d. of caffeine and 4-HAQO than after treatment with 4-HAQO alone. The possible mechanism of the effect of caffeine on pancreatic tumorigenesis induced by 4-HAQO in rats is discussed.Keywords
This publication has 4 references indexed in Scilit:
- Differential antimutagenic effects of caffeine and the protease inhibitor antipain on mutagenesis by various mutagens in Escherichia coliMutation Research, 1980
- Pancreatic tumors induced by a single intraperitoneal injection of azaserine in partial pancreatectomized ratsCancer Letters, 1980
- DNA repair and its coupling to DNA replication in eukaryotic cellsBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1978
- ENHANCING EFFECT OF PARTIAL PANCREATECTOMY AND ETHIONINE-INDUCED PANCREATIC REGENERATION ON TUMORIGENESIS OF AZASERINE IN RATS1978