Brief Communication: Transplantation Isoantigenicity of a Rat Sarcoma and Its Spontaneous Metastases2

Abstract

Two lung metastases, a lymph node metastasis, and the primary leg tumor from a single rat were assayed for antigen cross-reactivity by transplantation tests in the inbred strain of origin. The 4 tumor lines were implanted into the hind legs of groups of rats and excised 8 days later to induce immunity. After 21 days these groups were challenged intravenously (iv) with the complete range of tumor lines. The incidence and weights of tumors in the lung were assayed later and a significant degree of cross-protection to iv challenge was observed among all tumor lines, regardless of which line had been used to immunize the animals.