Mutagenesis by Photoactivation of Chlorpromazine, a Tranquilizer of the Phenothiazine Group

Abstract

The tranquilizer chlorpromazine, in combination with visible light or near-u.v. radiation, can cause base-pair substitution mutations and frameshift mutations in Salmonella typhimurium. The mutagenic damage is subject to repair by the bacterial excision~repair system.