The analysis of metabolite channelling in multienzyme complexes and multifunctional proteins
- 1 December 1989
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 264 (2), 605-607
- https://doi.org/10.1042/bj2640605
Abstract
Multienzyme complexes and multifunctional proteins may confer a kinetic advantage by channelling reaction intermediates between consecutive enzymes and reducing the transient time for the establishment of steady states. A general means for quantitatively assessing the contribution of channelling to the reduction of pool size and transient time is presented. Restrictions to the kinetic advantage are identified, and it is shown that no channelling advantage is obtained at high enzyme concentration or for enzymes which exhibit rapid-equilibrium kinetic behaviour.This publication has 11 references indexed in Scilit:
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