The reduction of SU-4885 by adrenal glands and other tissues and its inhibition by ACTH
- 1 May 1968
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 46 (5), 463-469
- https://doi.org/10.1139/o68-070
Abstract
Rat adrenal glands convert 2-methyl-l,2-bis(3-pyridyl)-l-propanone (SU-4885) [metopirone] in vitro to a product with physical and chemical properties indicating the reduction to 2-methyl-l,2-bis(3-pyridyIJ-1-propanol. The same compound is also formed by the reduction of SU-4485 with NaBH4. The reductionof SU-4885 also occurs in the presence of frog adrenal, rat kidney, and most actively, rat liver tissue, and depends on the concentration of SU-4885 in the incubation medium. Added deoxycorticosterone, at the concentration used, had no effect, but ACTH inhibited the reduction by both adrenal and liver tissue.This publication has 9 references indexed in Scilit:
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