Effects Of The (imBzl)D-His6, Des-Gly Analog Of GnRh On Gonadotropin And Estradiol Secretion In Normal Women
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Endocrine Research
- Vol. 10 (2), 163-170
- https://doi.org/10.3109/07435808409035416
Abstract
The acute gonadotropin and estradiol [E2] responses following single s.c. injections of 10, 50, 100 and 200 .mu.g of [(imBzl)D-His6, Pro9-NEt]-GnRH were compared to those after 100 .mu.g of [D-Trp6, Pro9-NEt]-GnRH. The gonadotropin responses after 50-100 .mu.g of the D-His analog of GnRH were equivalent to those following 100 .mu.g of the D-Trp analog. The ovarian E2 response, a reflectin of the total cumulative secretion of gonadotropins, was similar at 100 .mu.g of each analog. The E2 response paralleled the increasing gonadotropin response accompanying the graded doses of the D-His analog, indicating the lack of a direct inhibitory action of this GnRH agonist on the ovary. Assessment of both gonadotropin and E2 responses appears to be satisfactory for assessing relative potency among GnRH agonistic analogs.This publication has 6 references indexed in Scilit:
- STIMULATION OF LH FRAGMENTS WITH REDUCED BIOACTIVITY FOLLOWING GnRH AGONIST ADMINISTRATION IN WOMENJournal of Clinical Endocrinology & Metabolism, 1984
- Absence of gonadotropin-releasing hormone receptors in human gonadal tissueNature, 1982
- “MEDICAL OOPHORECTOMY” USING A LONG-ACTING GNRH AGONIST-A POSSIBLE NEW APPROACH TO THE TREATMENT OF ENDOMETRIOSIS.Journal of Clinical Endocrinology & Metabolism, 1982
- Extrapituitary Action of Gonadotropin-Releasing Hormone: Direct Inhibition Ovarian SteroidogenesisScience, 1979
- Circulating gonadotropins, estrogens, and androgens in polycystic ovarian diseaseAmerican Journal of Obstetrics and Gynecology, 1975
- Disappearance Rates of Endogenous Follicle-Stimulating Hormone in Serum Following Surgical Hypophysectomy in ManJournal of Clinical Endocrinology & Metabolism, 1970