Endogenous Ligands Selecting T Cells Expressing Particular Vβ Elements
- 1 January 1992
- journal article
- review article
- Published by Taylor & Francis in International Reviews of Immunology
- Vol. 8 (4), 289-309
- https://doi.org/10.3109/08830189209053514
Abstract
It has recently become clear that the minor lymphocyte stimulatory antigens (Mls) and other endogenous ligands which lead to the partial or total deletion of T cells bearing particular Vβ segments are encoded by mouse mammary tumor virus (MMTV). We review here the genetic analyses of multiple Vβ11 and Vβ3 deletion ligands and demonstrate the involvement of MMTV in all examples. Several features of Mls and the Vβ11/Vβ3 deleting ligands identify them as members of the superantigen family. Bacterial superantigens are known to bind both MHC class II and the TCR in regions distinct from conventional peptide antigens. Within the MMTV genome, the 3’ LTR has been identified as encoding superantigen function. We present data demonstrating that in vitro translation identifies the major product of the open reading frame (ORF) within the 3’ LTR as a type II integral membrane glycoprotein. It is proposed that the type II membrane glycoprotein interacts with MHC and TCR in a manner analogous to the bacterial superantigens and distinct from conventional peptide antigen. Several unanswered questions regarding superantigen action remain; what determines total or partial deletion? How is Mls transferred between cells? These questions are addressed in the discussion.Keywords
This publication has 51 references indexed in Scilit:
- Selective Depletion in HIV Infection of T Cells that Bear Specific T Cell Receptor V β SequencesScience, 1991
- Mls — a retrovirus exploits the immune systemImmunology Today, 1991
- The genetic basis of negative selection of Tcrb-Vll+ T cellsImmunogenetics, 1991
- Differential reactivity of Vβ9 T cells to minor lymphocyte stimulating antigenin vitro andin vivoEuropean Journal of Immunology, 1991
- Self superantigens?Cell, 1990
- Vβ17 gene polymorphism in wild-derived mouse strains: Two amino acid substitutions in the Vβ17 region greatly alter T cell receptor specificityCell, 1990
- Tolerance in vivo and in vitroImmunological Reviews, 1990
- Linkage betweenTcrb-V and a gene responsible for deletion of Tcrb-V11 + T cellsImmunogenetics, 1990
- Molecular cloning and sequencing of the Mtv-1 LTR: Evidence for a LTR sequence alterationVirus Research, 1989
- T-cell antigen receptor genes and T-cell recognitionNature, 1988