Chronic Granulomatous Hepatitis

Abstract

Three cases are described in which a chronic relapsing febrile illness was associated with granulomas in the liver. None of the known causes of hepatic granulomas was present in these patients. In 2 patients there was clinical improvement after corticosteroid treatment, and this was associated with resolution of the histological changes on liver biopsy. These 3 cases support the concept that chronic granulomatous hepatitis of unknown etiology is a distinct entity.