Recurrence of Trichophyton Rubrum Infection During Treatment with Griseofulvin

Abstract

A 34-year-old white female patient was first seen on Aug. 23, 1958, with a severe Trichophyton rubrum infection of the skin of both feet and both lower legs, and of the right thigh anteriorly, which had been present for approximately seven years. All toenails, and both thumbnails were involved. She had received all types of treatment, including maximum x-ray. A positive culture of T. rubrum was obtained on Oct. 15, 1958. Positive scrapings were obtained on two previous occasions by us. T. rubrum had also been isolated four or five years previously by other dermatologists. Because the patient had marked pruritus and occasional inflammatory vesiculopustular lesions at the margin of the involved areas, she was given triamcinolone, starting with 4 mg. four times daily, on Aug. 23, 1958, and maintained at 8 to 12 mg. daily. This controlled most of the objective and subjective signs of mycotic infection, but when