Molecular Structure, Stereochemistry and Interactions of Steffimycin B, and DNA Binding Anthracycline Antibiotic
- 1 October 1985
- journal article
- research article
- Published by Taylor & Francis in Journal of Biomolecular Structure and Dynamics
- Vol. 3 (2), 377-385
- https://doi.org/10.1080/07391102.1985.10508424
Abstract
The crystal and molecular structure of anthracycline antibiotic steffimycin B(C29H320O13) has been determined by X-ray diffraction and the stereochemistry revealed. The orthorhombic crystals belong to space group P212121, with the dimensions; a = 8.253 (2), b = 8.198 (2), c = 40.850 (8) Å and Z = 4. Intensity data were collected for 2518 independent reflections. The structure was solved by direct methods and refined to an R value of 0.066 for 1410 reflections. The configuration in ring A is TR,8S,9S. Ring A adopts half chair conformation, while the sugar ring has the regular chair conformation. The molecule most probably binds to double helical DNA through intercalation and hydrogen bonding.This publication has 12 references indexed in Scilit:
- Molecular structure, absolute stereochemistry, and interactions of nogalamycin, a DNA-binding anthracycline antitumor antibioticJournal of the American Chemical Society, 1983
- Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).Proceedings of the National Academy of Sciences, 1980
- The crystal and molecular structure of carminomycin I hydrochloride monohydrateActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1977
- Structures of steffimycin and steffimycin BThe Journal of Organic Chemistry, 1977
- Steffimycin B, a new member of the steffimycin family: isolation and characterization.The Journal of Antibiotics, 1974
- The application of phase relationships to complex structures. III. The optimum use of phase relationshipsActa Crystallographica Section A, 1971
- X-ray scattering factors computed from numerical Hartree–Fock wave functionsActa Crystallographica Section A, 1968
- A new antibacterial agent (U-20,661) isolated from a streptomycete strainCellular and Molecular Life Sciences, 1967
- Mode of Action of Antibiotic U-20,661Journal of Bacteriology, 1967