Thyroxine and hypervitaminosis-A

Abstract

When injected into rats receiving excess of vit. A, thyroxin failed to counteract the effect of hypervitaminosis. Animals receiving both thyroxin and excess of vit. A ate less, lost wt. more rapidly, and died earlier than those receiving either agent alone. The inj. of thyroxin produced a temporary decrease in food intake, followed by a marked increase. No evidence was obtained for a specific antagonism between thyroxin and vit. A.