AN INHERITED X-LINKED SERUM SYSTEM IN MAN
Open Access
- 1 February 1966
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 123 (2), 379-397
- https://doi.org/10.1084/jem.123.2.379
Abstract
The detection of an inherited X-linked serum system in man, disclosed by a heteroantiserum made specific by absorption, is described. The antigen, demonstrated by the specific antiserum, probably resides in the [alpha]2-macroglobulin fraction of serum. The system has been named the Xm system, where X refers to the localization of the gene on the X chromosome, and the m indicates that the antigen is part of the [alpha]2-macroglobulin fraction. The distribution of phenotypes in unrelated individuals from 4 populations, as well as studies performed in families are consistent with an X-linked dominant mode of inheritance. One Xm(a-) daughter was found in a family where the father was Xm(a+). This finding is discussed with particular reference to the possible influence of sex and age on the development of the phenotype. This common X-linked marker is likely to prove useful in mapping the human X chromosome.This publication has 14 references indexed in Scilit:
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