Effects of Stimulation of the Cingulate Gyrus on Insulin Secretion

Abstract

The cingulate gyrus was electrically stimulated in dogs anesthetized with thiopental, and its effects on plasma insulin-like activity in pancreatic vein blood were analyzed with the bio-assay method using hypophysectomized, adrenalectomized rats. Stimulation of the rostral and dorsal parts of the cingulate gyrus resulted in a significant suppression of the elevated insulin-like activity in response to an intravenous load of glucose, whereas stimulation of the intermediate part of the cingulate gyrus was ineffective. In the absence of a glucose load, the basal level of insulin-like activity did not change significantly during and after stimulation of any part of the cingulate gyrus.