IncreasedO‐glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic β‐cells
Open Access
- 14 April 2004
- journal article
- fj express-summary
- Published by Wiley in The FASEB Journal
- Vol. 18 (9), 959-961
- https://doi.org/10.1096/fj.03-0725fje
Abstract
Because adverse effects of glucose were attributed to its increased routing through the hexosamine pathway (HBP), we inquired whether HBP activation affects pancreatic β-cell survival. Exposure of hu...Keywords
Funding Information
- Ministero dell’Istruzione, dell’Università e della Ricerca
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