ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR CHRONIC GRANULOCYTIC-LEUKEMIA

Abstract

Patients (18) with chronic granulocytic leukemia underwent allogeneic marrow transplantation from HLA-identical sibling donors. The preparative regimen included cyclophosphamide and 1000-1500 rad total body irradiation in either single or fractionated doses. Eleven patients were transplanted in blast crisis. One died too early to evaluate. Five had recurrent leukemia, 3 died of interstitial pneumonia (IP), and 2 are living in remission after 20 and 39 mo. One additional patient with blast crisis was transplanted while in remission after chemotherapy and is living in remission 28 mo. after transplantation. Two patients were transplanted in the accelerated phase; 1 died early of infection and 1 died of IP. Four were transplanted in the chronic phase; 1 died of IP, 1 with graft-vs.-host disease, and 2 are living in remission 11 and 25 mo. after transplantation.