Effect of Neurotomy on Succinic Dehydrogenase Activity of Muscle

Abstract

Denervation of the gastrocnemius muscle of the rat resulted in a reduction of the succinic dehydrogenase activity of the muscle, apparently related to the well known decrease in glycogen content of the muscle following neurotomy. In the denervated muscle gly-colysis proceeded less rapidly than in the contralateral normal muscle. Some evidence is presented that as the result of de-nervation there is an increase in the activity of some dehydrogenase system which appears to be sensitive to oxygen.