Effect of Atropine and Methylatropine on Human Vaginal Blood Flow, Sexual Arousal and Climax

Abstract

No experimental data on the regulatory mechanism of the change in vaginal blood flow occuring at sexual arousal exist. Six women were in a controlled laboratory study given atropine 0.035 mg/kg i.v. The basal vaginal blood flow was recorded by a heat probe kept at set temperature on the vaginal wall. During sexual stimulation the flow was increased as in women when no drugs are applied and orgasm was unaffected as well. The neurotransmitter was thought to be acetylcholine but present experiments suggest that it is not an atropine sensitive traditional muscarine transmission. Methylatropine was given in 5 subjects and neither in these cases any effect on the vaginal vascular response was observed.