Linkage between the loci for cystic fibrosis and paraoxonase
- 1 May 1986
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 29 (5), 374-377
- https://doi.org/10.1111/j.1399-0004.1986.tb00507.x
Abstract
In a material of 22 Danish, 26 Canadian, 10 Australian, 5 English and 5 American families with at least 2 children affected with cystic fibrosis (CF) a combined positive LOD score of 3.46 was found for the relationship cystic fibrosis-paraoxonase (PON) at recombination fraction θ= 0.07 in males and θ= 0.13 in females. Assuming a three allele model for PON the LOD score was 4.50 at the same recombination fractions. This confirms our earlier finding of an indication of CF-PON synteny.Keywords
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