THE EFFECT OF RELAXIN ON UTERINE PHOSPHORYLASE IN THE RAT1

Abstract
An injection of relaxin into estrogen-primed, spayed rats increases uterine phosphorylase a activity per unit weight of tissue. Similar results were obtained when estrogen was substituted for relaxin. The estrogen-priming requirement for the effect of relaxin, in this particular instance on uterine glycogen, was not met by priming with testosterone. In the spayed non-primed rat, relaxin increased total phosphorylase activity in the entire uterus as well as increasing the uterine weight. Over-all, relaxin and estrogen are very similar in their effects on phosphorylase activity.