Über Fibrinogen und ein gerinnungsförderndes Plasmaglobulin.

Abstract

Solu-tions of fibrinogen made by the method of Hammarsten and by that of Mellanby differ in that the former cannot be fractionated by salting out methods, while the latter is separated, by half-saturating with (NH4)2SO4, into 2 fractions. The precipitate, "coagulation globulin" appears to be identical with Mellanby''s prothrombase. The maximum flocculation occurs at pH 5.3-5.6. The speed of clotting does not appear to be dependent on the concn. of fibrinogen, but when the percentage falls below 0.04%, clot formation does not take place.