Studies in tissue metabolism

Abstract

A spontaneous mammary carcinoma was grafted into mice of the strain (C3H) in which the tumour appeared, in order to obtain a grafted carcinoma of the same genetic constitution as the host. Mice bearing (1) spontaneous mammary tumours, (2) primary tumours induced by inj. of methyl cholanthrene and (3) 2 strains of grafted tumours were treated with colchicine. The reactivity to colchicine increased from (1) to (3). Treatment with 2-methyl-naphtho-quinone and ascorbic acid does not alter the effect produced by colchicine.