Nerve Growth Factor Induces a Neurokinin-1 Receptor– Mediated Airway Hyperresponsiveness in Guinea Pigs
- 1 May 1999
- journal article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 159 (5), 1541-1544
- https://doi.org/10.1164/ajrccm.159.5.9808058
Abstract
Because asthmatic patients show increased nerve growth factor (NGF) serum levels, we examined the effect of NGF on airway function. Intravenously administered NGF potentiates the histamine- induced bronchoconstriction with a maximum of over 200% in anesthetized spontaneously breathing guinea pigs. Doses of 8 ng and 80 ng NGF/kg body weight induce a significant hyperresponsiveness to histamine. NGF itself does not affect airway reactivity. Airway hyperresponsiveness is observed 30 min and 3 h after NGF administration, and has disappeared after 24 h. The neurokinin-1 receptor antagonist SR 140333 completely blocks the NGF-induced hyperresponsiveness, pointing to a role for tachykinins. This is the first report showing a direct relation between peripherally administered NGF and airway hyperresponsiveness. Taking into consideration that plasma NGF levels have been shown to be elevated in asthmatic patients, our result points to an important role for NGF in the pathogenesis of asthma.Keywords
This publication has 34 references indexed in Scilit:
- Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptorsJournal of Allergy and Clinical Immunology, 1997
- The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependentNeuroReport, 1997
- Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation.JCI Insight, 1996
- Nerve growth factor: from neurotrophin to neurokineTrends in Neurosciences, 1996
- Tachykinins, sensory nerves, and asthma—an overviewCanadian Journal of Physiology and Pharmacology, 1995
- Tumor necrosis factor is markedly synergistic with interleukin 1 and interferon‐γ in stimulating the production of nerve growth factor in fibroblastsFEBS Letters, 1994
- Neurotrophin induced second messenger responses in rat brain synaptosomesNeuroReport, 1993
- Cytokine Regulation of Nerve Growth Factor‐Mediated Cholinergic Neurotrophic Activity Synthesized by Astrocytes and FibroblastsJournal of Neurochemistry, 1992
- Nerve growth factor regulates expression of neuropeptide genes in adult sensory neuronsNature, 1989
- Isolation and partial amino acid sequence analysis of nerve growth factor from the guinea pig prostateJournal of Neuroscience Research, 1981