ND1 a New Neutrophil Granulocyte Antigen

Abstract

The serum of 2 patients suffering from autoimmune neutrophil granulocytopenia contained autoantibodies that were directed against a new granulocyte-specific antigen. Genetic analysis showed that this new antigen was not correlated with the already known neutrophil antigens NA1, NA2, NB1, NC1 or 9a. This was studied in a 4-generation family. In the Dutch population the frequency of the antigen, tentatively called ND1, is 98.5% (n = 67), pointing to a gene frequency of 0.88.