Chronic Catheterization of the Renal Artery: Technic for Studying Direct Effects of Substances on Kidney Function.

Abstract

A method was developed for chronic catheterization of the renal artery, with collection of urine from each kidney separately. Such a technique affords the opportunity of studying the direct effect of salt solutions, hormones and drugs injected directly into the renal artery of the unanesthetized dog, using the opposite kidney as a control. Preliminary studies with infusion of hypertonic saline into the renal artery of the dog in congestive heart failure indicate a marked increase in tubular reabsorption of Na.