Axonal Self-Destruction and Neurodegeneration
Top Cited Papers
- 3 May 2002
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 296 (5569), 868-871
- https://doi.org/10.1126/science.1068613
Abstract
Neurons seem to have at least two self-destruct programs. Like other cell types, they have an intracellular death program for undergoing apoptosis when they are injured, infected, or not needed. In addition, they apparently have a second, molecularly distinct self-destruct program in their axon. This program is activated when the axon is severed and leads to the rapid degeneration of the isolated part of the cut axon. Do neurons also use this second program to prune their axonal tree during development and to conserve resources in response to chronic insults?Keywords
This publication has 51 references indexed in Scilit:
- Compartmental neurodegeneration and synaptic plasticity in the Wlds mutant mouseThe Journal of Physiology, 2001
- Does apoptosis have a role in neurodegeneration?BMJ, 2001
- The Gene for Slow Wallerian Degeneration (Wlds) Is Also Protective against Vincristine NeuropathyNeurobiology of Disease, 2001
- BCL-2 FAMILY: Regulators of Cell DeathAnnual Review of Immunology, 1998
- Loss of the Compound Action Potential: an Electrophysiological, Biochemical and Morphological Study of Early Events in Axonal Degeneration in the C57BL/Ola MouseEuropean Journal of Neuroscience, 1994
- Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortexNeuron, 1993
- Prolonged survival of transected nerve fibres in C57BL/Ola mice is an intrinsic characteristic of the axonJournal of Neurocytology, 1993
- Axonal atrophy in sensory nerves of the diabetic BB‐Wistar rat: A possible early correlate of human diabetic neuropathyAnnals of Neurology, 1983
- Development of sympathetic neurons in compartmentalized culturesDevelopmental Biology, 1982
- XX. Experiments on the section of the glossopharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibresPhilosophical Transactions of the Royal Society of London, 1850