Effects of Ethanol on the NMR Characteristics of Rat Brain
- 1 December 1989
- journal article
- research article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 155 (6), 818-821
- https://doi.org/10.1192/bjp.155.6.818
Abstract
In rats, neither acute administration of ethanol nor the establishment of ethanol dependence by chronic administration for 28 days produced significant 1H-NMR relaxation changes. However, chronic ethanol intake for six months produced a transient rise in T1, with no change in T2 or water content. The significance of these results for study in man is discussed and a hypothesis is proposed to explain discrepant differences between T1, T2 and water content. It is suggested that T1 change with long-term ethanol exposure is related to altered free/bound water state secondary to cell membrane changes.This publication has 8 references indexed in Scilit:
- The effect of moderate blood alcohol levels on T1 and T2 relaxation times in the brains of normal volunteersMagnetic Resonance in Medicine, 1987
- BRAIN WATER MEASURED IN VOLUNTEERS AFTER ALCOHOL AND VASOPRESSINThe Lancet, 1985
- BRAIN WATER IN CHRONIC ALCOHOLIC PATIENTS MEASURED BY MAGNETIC RESONANCE IMAGINGThe Lancet, 1985
- Biomedical implications of the relaxation behaviour of water related to NMR imagingThe British Journal of Radiology, 1984
- Effects of carnitine on changes caused by chronic administration of alcoholNeuropharmacology, 1984
- Synaptosomal membrane lipids of mice during continuous exposure to ethanolJournal of Pharmacy and Pharmacology, 1977
- Drug Tolerance in Biomembranes: A Spin Label Study of the Effects of EthanolScience, 1977
- General Depressant Drug Dependency: A Biophysical HypothesisAdvances in Experimental Medicine and Biology, 1975