Muscle: A Three Phase System
Open Access
- 1 September 1959
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 43 (1), 55-79
- https://doi.org/10.1085/jgp.43.1.55
Abstract
The partition of Li+, Br-, and I- across the membrane of the sartorius muscle of the toad Bufo marinus has been investigated both at the steady state and with kinetic methods. Li+ was found to have access to an amount of muscle water similar to that of Na+. Br- and I- could be regarded as being interchangeable with cellular Cl-. None of the foreign ions caused significant losses of cellular K+. Li+ efflux from the cell was slower in muscles which were equilibrated for long periods in Li+ than in short equilibrated muscles. Na+ efflux from Li+-treated muscles was similar in rate to normal controls, but the amount of Na+ in the slow fraction was increased by Li+. I- efflux was extremely rapid, and it was not possible to differentiate kinetically between intra- and extracellular material. These results have been found to be consistent with the hypothesis of a three phase system for muscle.Keywords
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