Determination of Flecainide in Human Plasma by High Performance Liquid Chromatography with Fluorescence Detection
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 7 (1), 167-176
- https://doi.org/10.1080/01483918408073957
Abstract
A simple, rapid, selective and sensitive high-performance liquid chromatographic (HPLC) method for the monitoring of plasma flecainide [an antiarrhythmic agent] levels in a therapeutic or research environment is described. The drug is first separated from plasma by a single-step extraction with hexane and then quantitated by HPLC with fluorescence detection. Two linear ranges were established, i.e., 100-2000 ng/ml for drug monitoring in clinical management of patients and 3-300 ng/ml for pharmacokinetic studies. The intra-day variation is less than 6%.This publication has 5 references indexed in Scilit:
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