Oncogenicity in Marmosets of HL-23V, a Type C Oncornavirus Isolated From Human Leukemic Cells, and Comparison With Simian Sarcoma Virus Type 1 (SSV-1/SSAV-1) 2
- 1 April 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 58 (4), 1041-1046
- https://doi.org/10.1093/jnci/58.4.1041
Abstract
Type C virus produced by dog thymus cells (A7573) that were infected with virus (HL-23V), isolated from cultured leukocytes of an acute myelogenous leukemia patient, transformed marmoset and horse cells in vitro and induced virus-producing fibromas in marmosets. The tumors and transformed foci were indistinguishable morphologically from those induced by simian sarcoma virus, type 1 (SSV-1/SSAV-1). HL-23V was indistinguishable from SSV-1/SSAV-1 by immunofluorescence and neutralization tests, and the nontransforming virus associated with HL-23V completely inhibited SSV-1 focus induction in interference tests. Cell cultures established from a marmoset fibroma produced transforming and nontransforming virus biologically and antigenically indistinguishable from HL-23V and SSV-1/SSAV-1.Keywords
This publication has 2 references indexed in Scilit:
- Proviral sequences of baboon endogenous type C RNA virus in DNA of human leukaemic tissuesNature, 1976
- Primate type-C virus nucleic acid sequences (woolly monkey and baboon types) in tissues from a patient with acute myelogenous leukemia and in viruses isolated from cultured cells of the same patient.Proceedings of the National Academy of Sciences, 1976