Radioimmunoassay of Astroprotein (an Astrocyte-Specific Cerebroprotein) in Cerebrospinal Fluid From Patients with Glioma. A Preliminary Study

Abstract

Astroprotein, an astrocyte-specific cerebroprotein, in cerebrospinal fluid (CSF) and cyst fluid of tumors from 20 patients with brain tumors as well as other diseases has been measured by radioimmunoassay, and the following results were obtained: 1) Remarkably great amounts of astroprotein were detected in both CSF and cyst fluid of tumor from patients with glioblastoma. 2) Astroprotein in CSF from patients with brain tumors originated from other than astrocyte was found increased when the tumor was huge and was accompanied with severe fibrous gliosis. 3) Astroprotein in CSF from patients with other diseases than brain tumors was found generally minimal.