Estrone Inhibition of Cholesterol Biosynthesis at the Mevalonic Acid Stage

Abstract

Studies on the synthesis of cholesterol with cell-free homogenates of liver from rats treated with graded doses of estrone show that, at doses of estrone which cause a reduction in blood cholesterol, there is an accompanying inhibition of cholesterol biosynthesis. Furthermore, this inhibition appears to occur at the stage of cholesterol biosynthesis at which mevalonate is decarboxylated.