Enhancement of Memory Retrieval and Attenuation of Scopolamine-Induced Amnesia Following Administration of 5-HT3Antagonist ICS 205-930

Abstract

Experimental evidence suggests an important role of serotonin in the process of learning and memory. The present study investigated the effect of 5HT₃-receptor antagonist (ICS 205-930) on retrieval of a previously learned aversive habit in the mouse. The effect of ICS 205-930 on scopolamine (3 mg/kg) induced amnesia was also studied. ICS 205-930 (1, 10 & 100 μg/kg) produced a dose-dependent increase in latency to cross into the dark chamber. The scopolamine induced memory impairment was significantly attenuated by ICS 205-930 (10 μg/kg). These results suggest that memory deficits may be susceptible to attenuation with non-cholinergic treatments.