Wound Healing Influenced by Thyroxine and Thyrotrophic Hormone. A Tensiometric Study.

Abstract

Studies on the tensile strength of healing wounds in guinea pigs under the influence of thyroxine and thyrotropic hormone are reported. With the Sandblom-Petersen tensiom-eter the tensile strength of the wounds could be measured in living animals. The wounds of thyroidectomized guinea pigs possess the same tensile strength as those of intact controls. Thyroxine inhibits wound healing in intact as well as in thyroidectomized guinea pigs. Thyrotropic hormone inhibits wound-healing only in intact guinea pigs, whereas it does not appear to alter the normal course of healing in thyroidectomixed guinea pigs.