Comparative clinical evaluation of lofepramine and imipramine
- 1 January 1977
- journal article
- research article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 55 (1), 21-31
- https://doi.org/10.1111/j.1600-0447.1977.tb00137.x
Abstract
A multicenter comparative clinical evaluation of lofepramine, an imipramine analogue and imipramine was made double-blind technique and fixed dosage (lofepramine 70 mg t.i.d [3 .times./day], imipramine 50 mg t.i.d.). Plasma was drawn after 3 wk for determination of noradrenaline-uptake inhibitory capacity of the parent compound and/or its active metabolites. Plasma concentrations of lofepramine and desmethylimipramine (DMI) were determined in the same samples. The concentrations of lofepramine in the whole material were low (5-27 ng/ml) except for 1 patient who had a level of 53 ng/ml. In both groups of patients there was an almost 40-fold range in the plasma levels of DMI or apparent DMI. The patients were rated for severity of depression before treatment, then once weekly for 3 wk and finally during the 5th wk. A significant correlation was found between the concentrations of DMI and the noradrenaline-uptake inhibitory capacity in the plasma samples. No correlations were found between uptake inhibitory capacity of plasma samples and the amelioration scores.Keywords
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