APPARENT INSULIN ACTIVITY IN A FIBROSARCOMA ASSOCIATED WITH SPONTANEOUS HYPOGLYCEMIA*
- 1 May 1961
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 21 (5), 541-547
- https://doi.org/10.1210/jcem-21-5-541
Abstract
Using the glucose uptake of the isolated rat hemidiaphragm or the rat epididymal fat pad as an assay procedure, a glucose-uptake stimulator was extracted and concentrated from a large retroperitoneal fibrosarcoma removed from a patient with spontaneous hypoglycemia. Fractionation revealed the coexistence of an in vitro glucose-uptake inhibitor in the tumor. The glucose-uptake stimulating activity in a 22 per cent ethanol precipitate was destroyed by heating, but it was relatively heat-stable when in the form of the more concentrated zinc acetate precipitate. The stimulating activity was nondialyzable. The material which inhibited glucose uptake appeared to be heat-stable and dialyzable.Keywords
This publication has 1 reference indexed in Scilit:
- SPONTANEOUS HYPOGLYCEMIA ASSOCIATED WITH FIBROGENIC TUMOR: REPORT OF TWO CASESAnnals of Internal Medicine, 1957