Blood Substitutes
- 1 February 1996
- journal article
- review article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 82 (2), 390-405
- https://doi.org/10.1097/00000539-199602000-00032
Abstract
Oxygen-carrying volume-expanding solutions that can sustain life in the absence of red blood cells have been developed. Concerns about side effects, sources of hemoglobin, and the ultimate demonstration of efficacy will have to be satisfactorily addressed before anesthesiologists routinely administer such solutions in place of red cells during surgery.Keywords
This publication has 96 references indexed in Scilit:
- Cell-Free Hemoglobin Reverses the Endotoxin-Mediated Hyporesponsivity of Rat Aortic Rings to α-Adrenergic AgentsBiochemical and Biophysical Research Communications, 1994
- Acute effects of massive transfusion of a bovine hemoglobin blood substitute in a canine model of hemorrhagic shockEuropean Journal of Cardio-Thoracic Surgery, 1992
- Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophagesBiochemical and Biophysical Research Communications, 1991
- Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesisBiochemical and Biophysical Research Communications, 1990
- Collection and Transfusion of Blood in the United States, 1982–1988New England Journal of Medicine, 1990
- Exposure of Patients to Human Immunodeficiency Virus through the Transfusion of Blood Components That Test Antibody-NegativeNew England Journal of Medicine, 1989
- Hemodynamic, Metabolic, and Morphological Effects of Cardiopulmonary Bypass with a Fluorocarbon Priming SolutionThe Annals of Thoracic Surgery, 1986
- Preparation and in vitro characteristics of polymerized pyridoxylated hemoglobinTransfusion, 1983
- The Preoperative Treatment of Severely Anemic Patients with a Perfluorochemical Oxygen-Transport Fluid, Fluosol-DANew England Journal of Medicine, 1982
- THE RENAL HANDLING OF HEMOGLOBINThe Journal of Experimental Medicine, 1969