Effect of Antiheparin Agents on Venous Thrombosis Following Vascular Injury

Abstract

The effect of the antiheparin agents hexadimethrine bromide and protamine sulfate on venous thrombosis have been studied in the rat, rabbit, and dog. Untreated traumatized veins were not thrombosed. Traumatized veins treated with these agents topically, or in some species intravenously, thrombosed. The thrombi so produced consisted of an occluding mass of platelet trabeculae at the site of vascular injury, a red and white proximal tail, and a distal stasis clot. The hexadimethrine bromide-induced thrombus in the rat is prevented by pretreatment with Dicumarol or heparin. It is suggested that the antiheparin agents bring about thrombosis of the injured veins by neutralizing an anticoagulant liberated locally.