PROGNOSIS IN WELL DIFFERENTIATED NONINVASIVE CARCINOMA OF BLADDER BASED ON CHROMOSOMAL ANALYSIS

Abstract

In this series of 27 patients with well differentiated noninvasive carcinoma of the bladder, cytogenetic analysis repeatedly performed showed marker chromosomes in curative cystoscopic resections of 15 patients. In 14 of the 15 patients, recurrent carcinoma developed. Of the 12 patients without markers, 1 patient had a recurrence; the remaining 11 have been free of recurrence up to 8 yr after diagnosis. In this long term, although limited, experience with early carcinoma of the bladder, marker chromosomes were a highly accurate prognostic aid.