Networking with mitogen-activated protein kinases
- 1 November 1993
- journal article
- review article
- Published by Springer Nature in Molecular and Cellular Biochemistry
- Vol. 127-128 (1), 157-169
- https://doi.org/10.1007/bf01076767
Abstract
Mitogen activated protein (MAP) kinases and their target ribosomal protein S6 (RSK) kinases have been recognized as shared components in the intracellular signaling pathways of many diverse cytokines. Recent studies have extended this protein kinase cascade by identifying the major activator of vertebrate MAP kinases as a serine/threonine/tyrosine-protein kinase called MEK, which is related to yeast mating factor-regulated protein kinases encoded by the STE7 and byr1 genes. MEK, in turn, may be activated following its phosphorylation on serine by either of the kinases encoded by proto-oncogenesraf1 ormos, as well as by p78 mekk , which is related to the yeast STE11 and byr2 gene products. Isoforms of all of these protein kinases may specifically combine to assemble distinct modules for intracellular signal transmission. However, the fundamental architecture of these protein kinase cascades has been highly conserved during eukaryotic evolution.Keywords
This publication has 168 references indexed in Scilit:
- Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cellsFEBS Letters, 1992
- Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteinsFEBS Letters, 1992
- PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiaeJournal of General Microbiology, 1992
- Activation of the MAP kinase pathway by the protein kinase rafCell, 1992
- MAP kinase kinase from rabbit skeletal muscle A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone‐dependent signal transductionFEBS Letters, 1992
- Map kinases—ubiquitous signal transducers and potentially important components of the cell cycling machinery in eukaryotesCellular Signalling, 1992
- ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSKCell, 1992
- Signal Transduction During Pheromone Response in YeastAnnual Review of Cell Biology, 1991
- Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.Genes & Development, 1991
- Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilizationDevelopmental Biology, 1988