Induction of class II MHC antigens in vitro on pancreatic B cells isolated from BB/E rats
- 1 October 1986
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 29 (10), 749-751
- https://doi.org/10.1007/bf00870286
Abstract
The ability of recombinant Interferon-γ to induce class II expression in vitro on pancreatic islet B cells has been investigated by exposing islets isolated from BB/E and normal Wistar rats to Interferon- y and then staining successively with monoclonal antibodies specific for rat class II MHC antigens and insulin. Induction of class 11 expression was never observed on islet cells obtained from either normal Wistar rats or rats from the BB/E low diabetes incidence (< 2%) subline. In contrast, pancreatic B cells from rats from the BB/E high diabetes incidence (60–70%) subline expressed class II antigen following culture with Interferon-γ.Keywords
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