Molecular biology of vertebrate learning: Is c‐fos a new beginning?
- 1 March 1993
- journal article
- review article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 34 (4), 377-381
- https://doi.org/10.1002/jnr.490340402
Abstract
An elevated expression of c‐fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long‐term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c‐fos expression as well. On the basis of biological functions of the Fos protein, well known to be a component of a transcription factor, AP‐1, (activator protein 1) a hypothesis suggesting a role of transcription factors in the integration of information during learning processes is proposed.Keywords
This publication has 49 references indexed in Scilit:
- Expression of c-fos and other genes encoding transcription factors in long-term potentiationBehavioral and Neural Biology, 1992
- C-fos protooncogene expression in rat brain after long-term training of two-way active avoidance reactionBehavioural Brain Research, 1992
- Regulation of jun -B Messenger RNA and AP-1 Activity by Light and a Circadian ClockScience, 1992
- Synaptic Regulation of Immediate Early Gene Expression in Primary Cultures of Cortical NeuronsJournal of Neurochemistry, 1991
- L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genesNeuron, 1991
- Olfactory Recognition: A Simple Memory SystemScience, 1990
- Accumulation of c-fos mRNA in rat hippocampus during acquisition of a brightness discriminationBehavioral and Neural Biology, 1990
- The regulation and function of c-fos and other immediate early genes in the nervous systemNeuron, 1990
- Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanesthetized ratsNeuroscience Letters, 1989
- The mnemon and its juices: neuromodulation of memory processesBehavioral and Neural Biology, 1983