Enhancement of peripheral nerve regeneration by pharmacological activation of the cyclic amp second messenger system
- 1 January 1989
- journal article
- review article
- Published by Wiley in Microsurgery
- Vol. 10 (2), 122-125
- https://doi.org/10.1002/micr.1920100211
Abstract
This paper reviews the history of attempts to study peripheral nerve regeneration, focusing upon pharmacologic agents that may prove to be useful clinically. In particular, forskolin is described as a model for such an agent, and its mechanism of action, as a stimulator of the cyclic AMP second messenger system, is described.Keywords
This publication has 17 references indexed in Scilit:
- Recovery of free muscle grafts in rat: Improvement is associated with an increase in cyclic adenosine monophosphate concentration or use of the condition/test paradigmExperimental Neurology, 1987
- Chronic infusion of agents that increase cyclic AMP concentration enhances the regeneration of mammalian peripheral nerves in vivoExperimental Neurology, 1987
- Forskolin activation of adenylate cyclase in vivo stimulates nerve regenerationNature, 1984
- Effect of testosterone on the regeneration of the hypoglossal nerve in ratsExperimental Neurology, 1982
- Axonal transport of adenylate cyclase activity in normal and axotomized frog sciatic nerveBrain Research, 1982
- The effects of dibutyryl cyclic adenosine monophosphate on the degeneration and regeneration of crush-lesioned rat sciatic nervesNeuroscience, 1980
- ACTH accelerates recovery of neuromuscular function following crushing of peripheral nervePeptides, 1980
- Slowing of the rate of axonal regeneration during growth and maturationExperimental Neurology, 1979
- Axonal regeneration in the rat sciatic nerve: Effect of a conditioning lesion and of dbcAMPBrain Research, 1977
- Effects of Dibutyryl Cyclic AMP on Restoration of Function of Damaged Sciatic Nerve in RatsScience, 1973