The effects of alphavirus infection on neurons
- 13 May 1994
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 35 (S1), S23-S27
- https://doi.org/10.1002/ana.410350709
Abstract
Sindbis virus is an alphavirus that causes encephalitis in mice. The primary target cells for central nervous system infection are neurons. The outcome of neuronal infection is dependent on the age of the mouse at the time of infection (maturity of the neuron) and the strain of virus used for infection (virulence of the virus). Sindbis virus causes neuronal death by inducing apoptosis. As neurons mature, they become resistant to virus-induced apoptosis, resulting in a persistent infection. Host production of antibody to a viral surface glycoprotein acts to downregulate virus replication in the infected neurons by a noncytolytic mechanism and clears infectious virus from the central nervous system. Specific genetic changes in the virus result in more virulent strains that cause severe disease and sometimes death in mature animals. These same genetic alterations also confer the ability to ovrcome the resistance of neurons to induction of cell death. Therefore, mature neurons infected with virulent viruses do not recover from infection even in the presence of an adequate immune response.Keywords
This publication has 20 references indexed in Scilit:
- bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell deathCell, 1993
- The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 CellsJournal of Neurochemistry, 1993
- Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogeneNature, 1993
- Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-OncogeneScience, 1992
- Antibody-Mediated Clearance of Alphavirus Infection From NeuronsScience, 1991
- The regulation and expression of MHC class I genesImmunology Today, 1990
- Death and the cellImmunology Today, 1986
- Immunocytochemical identification and quantitation of the mononuclear cells in the cerebrospinal fluid, meninges, and brain during acute viral meningoencephalitis.The Journal of Experimental Medicine, 1984
- DISTRIBUTION AND QUANTITATION OF HLA-ABC AND DR (Ia) ANTIGENS ON HUMAN KIDNEY AND OTHER TISSUESTransplantation, 1980
- Age-dependent Resistance to Viral Encephalitis: Studies of Infections Due to Sindbis Virus in MiceThe Journal of Infectious Diseases, 1972