An Allele of the S(s) Blood Group Genes

Abstract

A blood group system defined by anti-U reacted with the red cells of all Caucasians tested and with the red cells of about 99% of American Negroes[long dash]the remaining 1% were assumed to be of the genotype uu. During the investigation of a second example of anti-U, we have found that the red cells of uu persons do not react with either anti-S or anti-s. The most obvious explanation is that u is an allele at the Ss locus of the MNSs system, and we suggest that Su is an appropriate symbol for this allele. Anti-U can most easily be thought of as anti-Ss.