Cation exchange—a common mechanism in the storage and release of biogenic amines stored in granules (vesicles)?
- 1 November 1983
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 119 (3), 225-234
- https://doi.org/10.1111/j.1748-1716.1983.tb07332.x
Abstract
Studies on the uptake and storage of sodium and biogenic amines (phenylethylamine, noradrenaline [norpinephrine], histamine) by 2 weak cation-exchangers, IRC-50 and Sephadex C-50, and by biogenic granule-enriched preparations [bovine nerve, mast cell and chromaffin granules] demonstrated that the synthetic and biogenic materials had several common characteristics. They showed similar concentration- and pH-dependence and fitted the same cation-exchange and receptor-binding equations. The matrices of amine-storing granules probably have the properties of weak cation-exchangers, with carboxyls as the cation-binding groups.Keywords
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