Excretion of Urinary Metabolites in Calcium Oxalate Urolithiasis

Abstract

Studies of the urinary excretion of a number of metabolites by normal adults and by persons suffering from chronic formation of calcium oxalate calculi have been made. The normal subjects excreted significantly less xanthurenic acid and 4-pyridoxic acid and more citric acid than the patients. Following administration of tryptophan, there was a marked rise in the excretion of oxalate. In all but two of the subjects, ingestion of vitamin B₆ was followed by a decrease in urinary oxalate.