Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum
- 30 March 2008
- journal article
- Published by Wolters Kluwer Health in AIDS
- Vol. 22 (6), 785-787
- https://doi.org/10.1097/qad.0b013e3282f560ee
Abstract
Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-α stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.Keywords
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