Influence of wheat bran on some reductive and hydrolytic activities of the rat cecal flora
- 1 January 1986
- journal article
- other
- Published by Taylor & Francis in Nutrition and Cancer
- Vol. 8 (2), 125-131
- https://doi.org/10.1080/01635588609513885
Abstract
For 30 days, male weanling rats were fed a semipurified, fiber‐free diet or a diet that contained 5, 15, or 30% (wt/wt) wheat bran. The activities of four cecal microbial enzymes were determined. Wheat bran significantly increased the wet weight content of the cecum and total bacterial count per cecum at the intermediate‐ and high‐treatment levels, but it had no effect on bacterial concentration per gram wet weight of cecal contents. Total β‐glucosidase and β‐glucuronidase activities per cecum were generally increased. Wheat bran decreased total nitrate reductase activity, but there was no change in total nitroreductase activity. Wheat bran significantly decreased enzyme activities for nitro‐ and nitrate reduction per gram of cecal contents but increased β‐glucosidase activity. The activities of the enzymes per 1011 bacteria followed a similar pattern to that noted per gram of cecal contents. Such fiber‐dependent changes in enzyme activity may alter the steady‐state concentration of toxic and genotoxic chemicals in the lumen of the hindgut.Keywords
This publication has 19 references indexed in Scilit:
- Effects of pectin-containing diets on the hepatic macromolecular covalent binding of 2,6-dinitro-[3H]toluene in Fischer-344 ratsToxicology and Applied Pharmacology, 1983
- Effects of wheat, rice, corn, and soybean bran on 1,2‐dimethylhydrazine‐induced large bowel tumorigenesis in F344 ratsNutrition and Cancer, 1983
- Dietary fibre, bacterial metabolism and toxicity of nitrate in the ratXenobiotica, 1982
- HIGH COLONIC pH PROMOTES COLORECTAL CANCERThe Lancet, 1981
- Effects of dietary bran and the colon carcinogen 1,2-dimethylhydrazine on faecal β-glucuronidase activity in miceFood and Cosmetics Toxicology, 1981
- COLONIC RESPONSE TO DIETARY FIBRE FROM CARROT, CABBAGE, APPLE, BRAN, AND GUAR GUMThe Lancet, 1978
- The effects of two dietary fiber supplements on gastrointestinal transit, stool weight and frequency, and bacterial flora, and fecal bile acids in normal subjectsMetabolism, 1977
- The influence of a diet rich in wheat fibre on the human faecal floraJournal of Medical Microbiology, 1976
- The aetiology of caecal enlargement in the ratFood and Cosmetics Toxicology, 1974
- Toxicologic implications of biotransformation by intestinal microfloraToxicology and Applied Pharmacology, 1972